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This article is about the fact that there are certain factors that have a huge impact on the activities of small and medium-sized enterprises in innovation on the example of the Republic of Kazakhstan. Indicators of SMEs are reflected in the economy of the people and their country. The author used statistical analysis of indicators of innovation-based growth in the Republic of Kazakhstan. Moreover, these figures were compared to those of developed countries, which were involved in such indicators as the share of innovation of active enterprises, domestic expenditure on R&D (as a percentage of gross domestic product). According to the survey the key factors that have a major impact on innovation by SMEs were identified.