Semiautomatic and fully functional electrochemical microanalyzer BO-05 suitable for scientific, didactic, and analytical applications: The use in the potentiometric analysis of  drugs

Włodzimierz Opoka; Marek Szlósarczyk; Adam Chojnacki; Agata Kryczyk-Poprawa; Przemysław Talik; József Gál; Bożena Muszyńska; Bogusław Baś

doi:10.14232/analecta.2021.1.64-72

Authors

Włodzimierz Opoka Department of Inorganic and Analytical Chemistry, Pharmaceutical Faculty, Medical College, Jagiellonian University, Poland https://orcid.org/0000-0003-3921-8632
Marek Szlósarczyk Department of Inorganic and Analytical Chemistry, Pharmaceutical Faculty, Medical College, Jagiellonian University, Poland https://orcid.org/0000-0002-3899-4077
Adam Chojnacki Department of Inorganic and Analytical Chemistry, Pharmaceutical Faculty, Medical College, Jagiellonian University, Poland
Agata Kryczyk-Poprawa Department of Inorganic and Analytical Chemistry, Pharmaceutical Faculty, Medical College, Jagiellonian University, Poland https://orcid.org/0000-0001-9125-250X
Przemysław Talik Department of Inorganic and Analytical Chemistry, Pharmaceutical Faculty, Medical College, Jagiellonian University, Poland https://orcid.org/0000-0002-5624-9302
József Gál University of Szeged, Faculty of Engineering, Hungary
Bożena Muszyńska Department of Pharmaceutical Botany, Pharmaceutical Faculty, Medical College, Jagiellonian University, Poland https://orcid.org/0000-0002-5007-1486
Bogusław Baś 4AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Poland https://orcid.org/0000-0002-5129-2942

DOI:

https://doi.org/10.14232/analecta.2021.1.64-72

Keywords:

potentiometric methods, potentiometric titration, electrochemical microanalyzer, verapamil hydrochloride

Abstract

This article presents the potentiometric method of determination of chlorides using the original BO-05 electrochemical microanalyzer. The quantification of chlorides is one of the frequently performed methods, both in the indirect determination of active pharmaceutical ingredients (API) and impurities in pharmaceutical raw materials, pharmacopoeial substances or pharmaceutical formulations as well. Successfully validated method was used to the analysis of chlorides in the preparations containing verapamil hydrochloride in form of tablets Staveran^® and Verapamil^®. The mean content of the studied API calculated to one tablet was close to the declared and equal to 123.6±1.5 mg and 122.6±1.1 mg, respectively. The presence of excipients have no significant impact on the final results. Thus shown that the electrochemical microanalyzer BO-05 is suitable for scientific, didactic and analytical applications.

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